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Renal Vascular and Glomerular Pathologies Associated with Spontaneous Hypertension in the Nonhuman Primate Chlorocebus aethiops sabaeus.

Rhoads MK, Goleva SB, Beierwaltes WH, Osborn JL. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 28:ajpregu.00026.2017. doi: 10.1152/ajpregu.00026.2017. PMID:28659284

http://ajpregu.physiology.org/content/ajpregu/early/2017/06/28/ajpregu.00026.2017.full.pdf

Megan Rhoads (USA)


 

1)      Summarize your work in one sentence.

Our work characterizes the prevalence and pathologies associated with spontaneous hypertension in 425 adult African Green Monkeys (Chlorocebus aethiops sabaeus) or commonly called vervet, a non-human primate species native to Africa and a highly invasive species in the West Indies.


2)      Summarize your findings in one sentence.

We find that hypertensive African Green Monkeys comprise approximately 1/3 of the phenotyped adult population, are older with elevated heart rates, and exhibit alterations in vascular and glomerular morphology compared to their normotensive controls.


3)      Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

We utilized forearm plethysmography to measure blood pressures, qPCR and radioimmunoassay to measure select components of the renin-angiotension-aldosterone system, and digital image analysis of fixed stained tissues.


4)      What did you learn from this paper, what was your take-home message?

This study shows that the African Green Monkey is a highly translational model of spontaneous hypertension with many similarities to human essential hypertension. We hope that studying the cause of spontaneous hypertension in this non-human primate species will lead to new advances in the treatment of human essential hypertension and associated renal and cardiovascular diseases.

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