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Large artery stiffness and carotid intima-media thickness in relation to markers of calcium and bone mineral metabolism in African women older than 46 years.

Gafane LFSchutte RKruger IMSchutte AE.

J Hum Hypertens. 2015 Mar;29(3):152-8. doi: 10.1038/jhh.2014.71. Epub 2014 Aug 14.

Lebo Gafane (South Africa)

1) Summarize your work in one sentence.

This study showed that in older predominantly postmenopausal South African women, blood pressure, large artery stiffness and carotid wall thickness were associated with calciotropic hormones and bone resorption, indicating a predisposition to arterial calcification.

2) Summarize your findings in one sentence.

In overweight/obese women, central pulse pressure (as a surrogate measure of arterial stiffness), was positively associated with alterations in bone metabolism and calciotropic hormones, whereas carotid-intima-media thickness of lean women was positively associated with parathyroid hormone:25-hydroxycholecalciferol (PTH:25(OH)D3).

3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

Bone mineral density (BMD) measurements were performed at the distal site of the non-dominant arm, using DTX 200 peripheral DXA system. All other measurements and analyses were performed according to standardised methods.

4) What did you learn from this paper, what was your take-home message?

In older African women, altered bone metabolism and associated calciotropic hormones play a role in the development of vascular calcification, which is associated with cardiovascular morbidity and mortality. The different associations in lean and overweight/obese women suggest different mechanisms at work regarding arterial calcification in states of low and high adiposity. These findings need confirmation in larger prospective and experimental studies to inform interventional strategies to reduce cardiovascular deterioration in older women.



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