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Joint Association of Low Vitamin D and Vitamin K Status with Blood Pressure and Hypertension.

van Ballegooijen AJ, Cepelis A, Visser M, Brouwer IA, van Schoor NM, Beulens JW. Hypertension. 2017 Jun;69(6):1165-1172. PMID: 28396533

Hanne van Ballegooijen (Netherlands)

Hanne van Ballegooijen is a post-doc at the Department of Health Sciences at Vrije Universiteit Amsterdam. Her research interests include nutrition and lifestyle determinants in the etiology of chronic diseases, especially cardiovascular diseases.

1) Summarize your work in one sentence.

To investigate whether the combination of low vitamin D and K status is associated with higher systolic and diastolic blood pressure and incident hypertension in older Dutch participants free of hypertension at baseline.

2) Summarize your findings in one sentence.

The combination of low vitamin D and K status was associated with increased blood pressure and a trend for greater hypertension risk.

3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

The LASA study is an ongoing cohort study that determines predictors and consequences of ageing. At baseline, each study participants underwent a physical examination and a blood sample was collected. The blood sample was used to measure circulating vitamin D and vitamin K status. Study participants underwent 3 more follow-up examination and systolic and diastolic blood pressure was measured at each examination. Participants who started using antihypertensive mediation during follow-up were only included up to the point of antihypertensive medication use. For the incident hypertension analysis, participants with prevalent hypertension at baseline were excluded based on blood pressure 140/90 mmHg or use of blood pressure lowering medication.

4) What did you learn from this paper, what was your take-home message?

Only the combination of low vitamin D and low vitamin K status was associated with increased systolic and diastolic blood pressure in a cohort of older men and women. A similar trend was seen for incident hypertension risk. As more is discovered about the powerful combination of vitamin D and K, it gives a renewed reason to eat a healthy diet including a variety of foods such as vegetables and fermented dairy for cardiovascular health.





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