International Society of Hypertension

New Investigators Network

What's On My Desk


Fadi Charchar, Ballarat, Australia

Posted on 31/03/2016

The latest What's on my desk contribution comes from Professor Fadi Charchar, ISH New Investigator Committee member from Federation University, Ballarat, Australia. Read on to find out why long non-coding RNAs are the sexiest molecules on the block currently.

Fadi CharcharMelanoma addiction to the long non-coding RNA SAMMSON.

Eleonora Leucci, Roberto Vendramin, Marco Spinazzi, Patrick Laurette, Mark Fiers, Jasper Wouters, Enrico Radaelli, Sven Eyckerman, Carina Leonelli, Katrien Vanderheyden, Aljosja Rogiers, Els Hermans, Pieter Baatsen, Stein Aerts, Frederic Amant, Stefan Van Aelst, Joost van den Oord, Bart de Strooper, Irwin Davidson, Denis L. J. Lafontaine, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh & Jean-Christophe Marine

Nature 531, 518–522 (24 March 2016) doi:10.1038/nature17161

Genome-wide identification of long noncoding RNAs in rat models of cardiovascular and renal disease.

Gopalakrishnan K, Kumarasamy S, Mell B, Joe B

Hypertension. 2015 Jan;65(1):200-10.


Long non-coding RNAs are the sexiest molecules on the block currently. This is an Interesting long non-coding RNA that is essential for Melanoma. A recent paper by the Bina Joe Lab in the US gave us a taster on the involvement of these molecules in the SHR and Dahl Salt sensitive-strain. We are studying non-coding RNA in human hypertension and my guess is that we will soon see more of these molecules as RNA based therapies.

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