International Society of Hypertension

Major Clinical Trial on Hypertension indicates the importance of intensive treatment

It has been a while since there has been a landmark clinical trial on hypertension and I would like to bring the following important paper and accompanying Commentaries to your attention:

'A Randomized Trial of Intensive versus Standard Blood-Pressure Control. The SPRINT Research Group. New Eng J Med November 9, 2015DOI: 10.1056/NEJMoa1511939'

This study investigated the most appropriate targets for systolic blood pressure to reduce cardiovascular morbidity and mortality among persons without diabetes. The trial, funded by the NIH, showed that intensive treatment to achieve a target of systolic blood pressure of 120 mmHg rather than 140 mmHg reduced cardiovascular morbidity and death by almost 30%. This study clearly shows that more intensive blood pressure control can save lives. 

Please read the paper and commentaries and look out for a report on the SPRINT study by Profs Lindholm and Poulter in the December ISH of the ISH Newsletter - Hypertension News.

Your President, Rhian


Editorial Commentaries

SPRINT, or False Start, Toward a Lower Universal-Treated Blood Pressure Target in Hypertension
Murray Esler
Hypertension. Originally published November 9, 2015. doi: 10.1161/HYPERTENSIONAHA.115.06735
http://hyper.ahajournals.org/content/early/2015/11/09/HYPERTENSIONAHA.115.06735
 
Successes of SPRINT, but Still Some Hurdles to Cross
Rhian M. Touyz, Anna F. Dominiczak
Hypertension. Originally published November 10, 2015. doi: 10.1161/HYPERTENSIONAHA.115.06725
http://hyper.ahajournals.org/content/early/2015/11/09/HYPERTENSIONAHA.115.06725
 
SPRINT Trial Results: Latest News in Hypertension Management
William C. Cushman, Paul K. Whelton, Lawrence J. Fine, Jackson T. Wright, Jr, David M. Reboussin, Karen C. Johnson, and Suzanne Oparil
Hypertension. Originally published November 9, 2015. doi: 10.1161/HYPERTENSIONAHA.115.06722
http://hyper.ahajournals.org/ content/early/2015/11/09/ HYPERTENSIONAHA.115.06722
 
SPRINT: What Remains Unanswered and Where Do We Go From Here?
Daniel W. Jones, Lyssa Weatherly, and John E. Hall
Hypertension. Originally published November 9, 2015. doi: 10.1161/HYPERTENSIONAHA.115.06723
http://hyper.ahajournals.org/content/early/2015/11/09/HYPERTENSIONAHA.115.06723

 

 

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