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Longitudinal changes in excess pressure independently predict declining renal function among healthy individuals - a pilot study. 

Climie RED, Picone DS, Sharman JE. American Journal of Hypertension, 2017;1;30(8):772-775.

https://academic.oup.com/ajh/article/30/8/772/3858280

Rachel Climie (France) 


1) Summarize your work in one sentence.

This was the first longitudinal study of the association between the change in aortic reservoir characteristics (novel approach to measuring the pressure wave) and kidney function in healthy individuals.


2) Summarize your findings in one sentence.

We showed that excess pressure (a potential marker of vascular dysfunction and analogous to a flow wave) is independently associated with a decline in kidney function among healthy people followed over 3 years.


3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

Models of arterial wave propagation have been employed to better understand the contribution of waveform morphology to cardiovascular disease risk, with one approach being the aortic reservoir paradigm (used in our study). The aortic reservoir model interprets the measured aortic pressure as the sum of a reservoir pressure (related to compliance and representative of the cyclic changes in aortic volume) and an excess pressure component. This approach has potential advantages over traditional methods for determining pressure wave propagation.


4) What did you learn from this paper, what was your take-home message?

This was the first longitudinal study of aortic reservoir characteristics and demonstrated that excess pressure is independently associated with a decline in renal function among healthy individuals. Our findings need to be confirmed in larger cohorts and also in at risk populations. Nonetheless, given the novel findings, our take-home message is that there is a need to better understand the underlying physiological determinants of aortic reservoir function which may help to explain accelerated organ dama

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