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The relation of blood pressure and carotid intima-media thickness with the glutathione cycle in a young bi-ethnic population: the African-PREDICT study.

Myburgh C, Huisman HW, Mels CMC.

J Hum Hypertens. 2018 Apr;32(4):268-277. doi: 10.1038/s41371-018-0044-3.

Caitlynd Myburgh (South Africa)

1) Summarize your work in one sentence.

In light of previous links found between oxidative stress and hypertension, also in our own South African population, we investigated oxidative stress profiles in black and white men and women and how these profiles relate with blood pressure and measures of arterial stiffness and atherosclerosis in young, apparently healthy cohort.  

2) Summarize your findings in one sentence.

We found a negative association between 24h pulse pressure and glutathione peroxidase activity in young, healthy black men, suggesting a role for lower glutathione peroxidase activity in early vascular compromise in this group, while all other groups displayed a physiological role of reactive oxygen species in blood pressure regulation.

3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

We made use of the CardioXplore 24hr ambulatory blood pressure monitoring system and the General Electric Vivid E9 B-mode ultrasonography device to measure blood pressure and carotid intima-media thickness respectively. We also measured glutathione peroxidase and glutathione reductase enzyme activities as part of the glutathione system using the Cobas Integra 400 plus.

4) What did you learn from this paper, what was your take-home message?

Although South Africa is plagued by hypertension, black South Africans display a clear association of oxidative stress with blood pressure and early vascular aging, evident even in a young and healthy population.


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