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Leptin and its Relation to Autonomic Activity, Endothelial Cell Activation and Blood Pressure in a Young Black and White Population: The African-PREDICT study.

Horm Metab Res. 2018 Mar;50(3):257-266. doi: 10.1055/s-0043-122236.

Blessing Ahiante (South Africa)
PhD researcher in the Hypertension in Africa Research Team, North-West University, South Africa. E-mail:


1) Summarize your work in one sentence.

We investigated leptin and its association with measures of autonomic function, endothelial activation, and blood pressure in 820 young healthy black and white men and women between the ages of 20-30 years.

2) Summarize your findings in one sentence.

Despite the almost 10-fold higher leptin levels in women than men, only men showed an independent association between markers of autonomic activity with leptin. Furthermore, only in white men did 24-hour diastolic blood pressure associate positively with leptin and was partly mediated by autonomic function.

3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

We determined serum leptin and endothelial cellular adhesion molecules and also measured 24-hour blood pressure, heart rate and heart rate variability components.

4) What did you learn from this paper, what was your take-home message?

Leptin’s independent association with autonomic neural activity in young healthy adults suggests an early influence of leptin on autonomic function, which may result in future blood pressure elevation, especially in men.


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