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High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension

Erika S. Jones, J. David Spence, Adam D. Mcintyre, Justus Nondi, Kennedy Gogo, Adeseye Akintunde, Daniel G. Hackam, Brian L. Rayner

Am J Hypertens, 2017; 30(5):478–483

https://doi.org/10.1093/ajh/hpw167

Erika Jones (South Africa)


1) Summarize your work in one sentence.

Patients with resistant hypertension were phenotyped according to aldosterone and renin, after which, selected candidate genes were sequenced.


2) Summarize your findings in one sentence.

Numerous genetic variants of candidate genes (including the mineralocorticoid receptor, beta subunit of the epithelial sodium channel, G protein coupled receptor and uromodulin) were detected, not all of which have been previously described.


3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

Patients with resistant hypertension were phenotyped according to renin and aldosterone levels. Based on these levels candidate genes were sequenced and variants were documented. 


4) What did you learn from this paper, what was your take-home message?

A large number of variants were detected in the selected candidate genes. These variants contribute to understanding the underlying mechanisms causing resistant hypertension in people of Black African origins.

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