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Atherosclerosis of the carotid bulb is associated with the severity of orthostatic hypotension in non-diabetic adult patients: a cross-sectional study.

Kobayashi Y, Ishiguro H, Fujikawa T, Kobayashi H, Sumida K, Kagimoto M, Okuyama Y, Ehara Y, Katsumata M, Fujita M, Fujiwara A, Saka S, Yatsu K, Hirawa N, Toya Y, Yasuda G, Umemura S, Tamura K.

Clin Exp Hypertens. 2018 Apr 19:1-8.

Yusuke Kobayashi (Japan)


1) Summarize your work in one sentence.

As our country is now the leading aging country, we aim at extending healthy life span and achieve successful aging by basic, clinical and translational research in the field of life-style related diseases.


2) Summarize your findings in one sentence.

This is the first report showed that atherosclerosis of the carotid bulb, assessed by intima-media thickness (IMT), is closely associated with orthostatic hypotension (OH), which may threaten the QOL of elderly by risk of fall and syncope.


3) Which were the more important methods you used in this work? If it is not a traditional method you can briefly explain the concept of that methodology.

Most of the studies measured IMT of the common carotid artery, however, we focused on IMT of the carotid bulb, which is considered to have high dense of baroreceptors. We used “Kiritsu Meijin (Crosswell, Japan)”, a soft ware for measuring real-time heart rate variability, as an index for baroreceptor function.


4) What did you learn from this paper, what was your take-home message?

By checking the carotid bulb IMT with ultrasonography, we can easily detect 1) early atherosclerotic change, 2) systemic arterial stiffening, 3) impaired baroreceptor function, 4) severity of OH and also, 5) a risk of cardiovascular and cerebrovascular diseases.

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