Jan Danser, Erasmus Medical Centre, Rotterdam, The Netherlands
Posted on 13/07/2018
Find out what Jan Danser Erasmus Medical Centre, Rotterdam, The Netherlands (winner of the ISH 2018 Distinguished Mentor Award) is reading right now.
Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice
Why I selected this manuscript?
It describes a study in mice with a modified Edn1 allele that increases mRNA stability and thereby elevates ET-1 levels. By making use of heterozygous pregnant females, as well as wildtype females mated with heterozygous males, the authors are capable of distinguishing in a very elegant way the contribution of maternal ET-1 and fetal ET-1 in pregnancy. It turns out that high maternal ET-1 production causes a preeclampsia-like phenotype, while fetal ET-1 increases the levels of the VEGF-inactivating factor sFlt-1, thus additionally contributing to blood pressure elevation. In a previous study in pregnant women with and without preeclampsia (Verdonk et al., Hypertension 2015), we observed a close relationship between ET-1, blood pressure and sFlt-1, and the current study now unravels the underlying cause of this relationship. Both studies suggest that ET receptor antagonists might be a promising tool to treat preeclampsia.