From RAG to Riches And Back Again: always keep an eye on our mice models
(A Hot off the Press report from the June 2017 issue of ISH Hypertension News)
Kathryn Sandberg and her team very recently conducted a study1, to be published in the June 2017 issue of Hypertension, focusing on the loss of resistance to angiotensin II–induced hypertension in Recombination-Activating Gene 1 knockout mice (Rag1-/-) on the C57BL/6J background (Jackson Laboratory). This mouse model is deficient in functional T and B cells due to the lack of the V-D-J recombination enzyme, and has been used by several groups in the past decade to explore the involvement of the adaptive immune arm in hypertension.
ISH Hypertension News is available online @ http://ish-world.com/news/a/hypertensionnews/, ISSN: 2520-2782
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